Researching Mitigation of Alcohol Binge Drinking in Polydrug Abuse

Journal of Personalized Medicine, 2022

Summary:
This commentary explores how genetic risk polymorphisms in the KCNK13 and RASGRF2 genes, along with the Genetic Addiction Risk Score (GARS), can guide precision pro-dopamine regulation to reduce binge drinking and relapse. Animal and human studies with the neuro-nutrient KB220 show promising results in mitigating alcohol-seeking behaviors and enhancing brain connectivity in reward circuits.

Coupling Genetic Addiction Risk Score (GARS) and Pro Dopamine Regulation (KB220) to Combat Substance Use Disorder (SUD)

Global Journal of Addiction & Rehabilitation Medicine, 2017

Summary:
This editorial introduces a structured approach to treating Reward Deficiency Syndrome (RDS) by combining GARS testing, behavioral assessments, and KB220 amino acid therapy. The strategy aims to restore dopamine homeostasis, reduce relapse, and personalize addiction treatment based on genetic profiles. Includes a comprehensive table summarizing KB220 clinical trials from 1973–2016.

Determinism v. Free Will & Genetic Evidence of Addiction in Plea Bargaining and Sentence Mitigation

St. Mary’s Law Journal, 2022

Summary:
This legal article presents a case study where genetic addiction evidence (GARS) was successfully used in court to argue for rehabilitation over incarceration in a felony DUI case. It discusses the implications of genetic determinism versus free will in the legal system and proposes using GARS to support sentence mitigation for offenders with diagnosed substance use disorders.

The Benefits of Genetic Addiction Risk Score (GARS™) Testing in Substance Use Disorder (SUD)

International Journal of Genomics and Data Mining

Summary:
This comprehensive review discusses the clinical applications of GARS testing to identify genetic vulnerability to addiction. The paper outlines how GARS can help with treatment personalization, guilt reduction, insurance justification, medication dosing (especially MATs), and optimizing resource allocation. It provides technical detail on the panel’s genes and polymorphisms as well as clinical case benefits.

Neurodynamics of Relapse Prevention: A Neuronutrient Approach to Outpatient DUI Offenders

Journal of Psychoactive Drugs, 1990

Summary:
This early study examined the effects of amino acid formulations (e.g., SAAVE and Tropamine, precursors to KB220) on relapse prevention among outpatient DUI offenders. Over a 10-week program, participants receiving the neuronutrient supplements showed significant reductions in relapse rates and substance use compared to controls .

Genetic Addiction Risk Severity Assessment Identifies Polymorphic Reward Genes as Antecedents to Reward Deficiency Syndrome (RDS)

Journal of Personalized Medicine, 2022

Summary:
This case study of a nuclear family shows how GARS testing revealed multigenerational genetic vulnerabilities to RDS behaviors such as alcoholism, anxiety, and depression. The results reduced stigma and personal guilt while supporting targeted dopamine regulation interventions. The paper reinforces the predictive power of GARS based on the number of risk alleles across dopamine and reward genes.